No matter how miserable the trials and suffering we go through in this life, Jesus is right there with us. He manifests himself through the Spirit, but also through the love and support of friends, family members, and community. Jesus is there even in the suffering.
That's how I know God is real. It's becoming ever more popular to not believe in God. I'll admit, sometimes it seems like a very abstract existence. However, when situations like this happen I cannot deny His existence.